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Neurotoxic amino acids: aspartic acid and phenylalanine, without the other amino acids in protein, are neurotoxic and damage the neurons in the brain.

Analgesic: a drug that alleviates or eliminates pain from any cause without changing other sensations.

Antibiotics: an antimicrobial substance, produced by microorganisms or synthetically, used in the treatment of infectious diseases.

Platelet antiaggregate: a drug that prevents platelet adhesion, used in prophylactic or antithrombotic therapies.

Superficial temporal artery: The artery that runs through the lateral part of the head, and can be easily felt in the area in front of the ear. It is often used to take someone's pulse. It crosses the zygomatic process of the temporal bone and, approximately 5 cm above this, splits into a frontal and a parietal branch.

Aspirin: a drug that belongs to the salicylate medication group. It is used to alleviate pain and to reduce fever.

Beta-blockers: used in the treatment of hypertension, angina of the chest and certain cardiac arrhythmias. They have a blocking effect on the sympathetic nervous system (the system that supplies nervous impulses to the smooth muscles and the heart, and has a close relationship with vascular secretions and movements), reducing the force and frequency of the contraction.

Chronic headache: pain occurring on a daily or almost daily basis, which can be similar to migraine, can behave like a tension headache or like a headache that is different to the previous ones but persistent.

Rebound headache: perpetuation of headache as a result of analgesic abuse.

Tension headache: headache with a muscular cause, such as the straightening of the spine and, as a result a loss of the normal curvature caused by muscular contraction or spasm.

Pulsating pain: pain occurring intermittently in the form of pulsations or rhythmic beats.

Ergotic: the name for alkaloid derivatives of ergot of rye.

Drug: chemical compound use in therapy. Refers to an agent or chemical substance, simple or compound, administered for therapeutic purposes.

Aura phase: the phase during which the particular sensation or phenomenon preceding the migraine attack occurs. It can be of a motor, sensory, vasomotor, secretory or psychic nature.

Cephalea phase: this is the phase during which headache appears. It is also common during this phase for other symptoms to present themselves, such as nausea and vomiting, photophobia and phonophobia.

Resolution phase: this is the stage during which the symptoms start to reduce gradually until they disappear.

Prodromal stage: the phase that occurs before the aura and cephalea phases.

Neurovascular disorder: changes in the nervous and vascular systems all at once.

Physiopathology: part of the pathology that studies functional disorders without looking at the possible anatomical lesions.

Flunarizine: a calcium antagonist used in the treatment of vertigo, which can lead to Parkinsonism.

Phonophobia: abnormal intolerance to sound or noises.

Photophobia: abnormal intolerance to light.

Oxidative mitochondrial function: the principal function of the mitochondrion, in bringing the final phase of aerobic metabolism to a close: oxidative phosphorylation. This means that it achieves an ATP benefit thanks to the passage of protons through the membrane of the mitochondrion, by means of a transmembrane protein that functions as ATP-ase.

Helicobacter pylori: bacterium of the helicobacter genus, casing various gastroduodenal disorders (ulcer, gastritis...)

Cortical hyperexcitability: an increase in nervous activity in the cerebral cortex.

Ictus: a localised neurological deficiency that appears acutely.

Migrainous infarction: partial or full persistence of some of the symptoms of the migraines aura after one week. Migrainous infarction is also diagnosed in cases where a cerebral infarction occurs, even if the symptoms do not persist.

Intracellular magnesium: a bioelement that is essential to life. It activates all reactions in which ATP is involved. Excesses or deficiencies can lead to pathologies.

Preventive medication: prophylaxis.

Migraine: periodic headache, often temporal and unilateral at the start, accompanied by nausea, vomiting, constipation or diarrhoea and photophobia.

Migracalm®: a healthcare product that applies continuous and controlled pressure to the superficial temporal arteries in the temple area, alleviating the pain caused by a migraine.

Neurologist: an expert on the nervous system and its diseases.

Osmophobia: abnormal intolerance to odours or perfumes.

Pathogenesis: the source and development of diseases.

Prophylaxis: a set of measures serving to protect individuals or society against diseases. Preventive treatment.

Riboflavin: Vitamin B2, the precursor to certain coenzymes that act on oxidoreduction reactions in the transfer of proteins and glucides to amino acids and fatty acids.

Triptans: a group of drugs with an analgesic and abortive action against migraine attacks.

Sodium valproate: belongs to the group of anticonvulsive medication. Used on their own or with other medication to control certain convulsions in the treatment of epilepsy.

Vasodilatation: dilation of the blood vessels, either as a result in the increase of intravascular pressure (passive vasodilatation) or the reduction in vasomotor pressure, caused by the relaxation of the vascular musculature.
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MIGRACALM® alleviates migraine pain by putting pressure on the superficial temporal arteries.
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